Basement membrane components are key players in specialized extracellular matrices
نویسندگان
چکیده
منابع مشابه
Basement membrane components.
I diopathic inflammatory bowel disease (IBD) collectively describes ulcerative colitis (UC) and Crohn’s disease (CD). UC is characterised by inflammation limited to the colonic mucosa and collagen deposition only in the submucosa, whereas CD is characterised by transmural, granulomatous inflammation and thickening of the bowel wall as a result of thickening of the muscularis layers and transmur...
متن کاملINTRODUCTION Basement membranes are specialized extracellular matrices that play fundamental roles in tissue development and function. These thin sheet-like structures are produced through complex interactions between the major components laminins, collagen IV, the heparan sulfate proteoglycan perlecan and nidogen
Basement membranes are specialized extracellular matrices that play fundamental roles in tissue development and function. These thin sheet-like structures are produced through complex interactions between the major components laminins, collagen IV, the heparan sulfate proteoglycan perlecan and nidogen (Mayer and Timpl, 1993). Laminins are heterotrimeric crossshaped multidomain molecules compose...
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Several monoclonal antibodies raised against a glycoprotein-enriched fraction of adult muscle membranes of Locusta migratoria selectively stain particles within haemocytes and basement membrane in developing locust embryos. Haemocytes containing immunoreactive particles are found associated with areas where basement membrane is being laid down. The underlying ectoderm does not show immunoreacti...
متن کاملActive Peptide-Conjugated Chitosan Matrices as an Artificial Basement Membrane
The basement membrane, a thin extracellular matrix, plays a critical role in tissue development and repair. Laminins are the major component of basement membrane and have diverse biological activities. We have identified various cell-adhesive peptides from laminins and their specific cell surface receptors. Polysaccharides, including chitosan, have been used as scaffolds, which regulate cellula...
متن کاملExpression of integrins and basement membrane components by wound keratinocytes.
Extracellular matrix proteins and their cellular receptors, integrins, play a fundamental role in keratinocyte adhesion and migration. During wound healing, keratinocytes detach, migrate until the two epithelial sheets confront, and then regenerate the basement membrane. We examined the expression of different integrins and their putative ligands in keratinocytes during human mucosal wound heal...
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ژورنال
عنوان ژورنال: Cellular and Molecular Life Sciences
سال: 2010
ISSN: 1420-682X,1420-9071
DOI: 10.1007/s00018-010-0367-x